Decay accelerating factor in guinea-pig reproductive organs
نویسندگان
چکیده
منابع مشابه
Decay-accelerating factor in guinea pig stomachs following ischemia reperfusion stress.
A complement regulatory protein, decay-accelerating factor (DAF, CD55), is known to protect host tissues from autologous complement activation. DAF is present on the apical side of human gastric epithelial cells, and its expression increases during gastritis. To develop an animal model for analysis of DAF expression on gastric cells, a mAb to guinea pig DAF was successfully used. Although DAF e...
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Decay-accelerating factor (DAF) ~ is a membrane protein that inhibits amplification of the complement cascade on cell surfaces. By binding to C3b or C4b complement fragments that accidentally deposit on the cell membrane, DAF blocks the assembly of both the classical and alternative C3 and C5 convertases (1-3). In this manner, DAF protects host cells from damage by autologous complement. DAF is...
متن کاملKaryotype of Hairless Guinea pig
Chromosomal patterns of experimental animals are useful tools for cytogenetics research and animal breeding. Chromosome investigations of the hairless guinea pig are rare, therefore, karyotype of hairless guinea pigs (twelve male and female) was studied using metaphase spreads of bone marrows and G banding techniques. The chromosomes diploid number was 2n= 64 and polymorphism of three type chro...
متن کاملCharacterization of the active sites in decay-accelerating factor.
Decay-accelerating factor (DAF) is a complement regulator that dissociates autologous C3 convertases, which assemble on self cell surfaces. Its activity resides in the last three of its four complement control protein repeats (CCP2-4). Previous modeling on the nuclear magnetic resonance structure of CCP15-16 in the serum C3 convertase regulator factor H proposed a positively charged surface are...
متن کاملDecay-accelerating factor in the periovulatory rat ovary.
One of the most prominent inflammatory reactions is the activation of the complement system. The activated complement system does not distinguish between pathogens and the host cell. In order to prevent autologous complement-mediated attack, host cells express a variety of both membrane-bound and fluid-phase complement regulatory proteins which control activity of the complement cascade by acti...
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ژورنال
عنوان ژورنال: Immunology
سال: 2000
ISSN: 0019-2805
DOI: 10.1046/j.1365-2567.2000.00010.x